
Enhancement of Research Quality through Automation :
The NOTABLE Advantage Ⅱ
Automation plays a pivotal role in advancing research quality by delivering precise, consistent results, thereby enhancing the credibility and reliability of scientific findings.
1. Precision
Automated systems are engineered to adhere strictly to established protocols, significantly reducing the risk of human error and enhancing the accuracy and reliability of experimental results. By minimizing errors and variability inherent in manual processes, the data quality is markedly improved. For instance, the NOTABLE automation system, when utilized for PCR preparation, yields CT (Threshold Cycle) values that are consistent with those obtained through manual preparation, demonstrating the system's precision.
One of the critical metrics for assessing the quality of PCR preparation is the R² value, which indicates the linearity of the reaction. Experiments conducted with NOTABLE exhibit R² values approaching 1 for serial dilution samples, indicating an exceptionally high level of accuracy in aspiration and dispensing. This precision is crucial for applications requiring rigorous quantification, such as gene expression analysis and viral load measurement.

Figure 1. Improved Results with NOTABLE. Results from ABLE Labs' qRT-PCR targeting microRNA demonstrate reproducible Ct values similar to manual results. Furthermore, high R2 values in qRT-PCR with NOTABLE indicate more precise aspiration and dispensing.
2. Consistency
Consistency in experimental procedures is essential for the reliability and reproducibility of scientific research. Automated systems ensure that experimental protocols are executed uniformly, significantly reducing the variability associated with manual processes. This uniformity is crucial for the comparability of results across different experiments and over time, thereby enhancing the overall reliability of research findings.
At ABLE Labs, the use of NOTABLE for PCR sample preparation has resulted in a more consistent distribution of coefficient of variation (CV) values, indicating reduced variability and enhanced reproducibility. This consistency extends beyond PCR preparation to other critical processes, such as nucleic acid extraction using NOTABLE’s Magnetic module. Consistent and reliable nucleic acid extraction is fundamental for downstream applications, including sequencing, cloning, and diagnostic assays.
Moreover, the robustness of automated systems like NOTABLE ensures that high standards of experimental quality are maintained regardless of changes in laboratory personnel. This is particularly important in research environments where staff turnover can disrupt experimental consistency and data integrity. By providing a stable and reproducible platform, NOTABLE mitigates the risks associated with human variability and turnover, ensuring continuity and reliability in research outcomes.

Figure 2. Consistent Data. NOTABLE provides consistent data in PCR sample preparation and nucleic acid extraction processes. This ensures improved research quality and guarantees reproducibility.

Enhancement of Research Quality through Automation :
The NOTABLE Advantage Ⅱ
Automation plays a pivotal role in advancing research quality by delivering precise, consistent results, thereby enhancing the credibility and reliability of scientific findings.
1. Precision
Automated systems are engineered to adhere strictly to established protocols, significantly reducing the risk of human error and enhancing the accuracy and reliability of experimental results. By minimizing errors and variability inherent in manual processes, the data quality is markedly improved. For instance, the NOTABLE automation system, when utilized for PCR preparation, yields CT (Threshold Cycle) values that are consistent with those obtained through manual preparation, demonstrating the system's precision.
One of the critical metrics for assessing the quality of PCR preparation is the R² value, which indicates the linearity of the reaction. Experiments conducted with NOTABLE exhibit R² values approaching 1 for serial dilution samples, indicating an exceptionally high level of accuracy in aspiration and dispensing. This precision is crucial for applications requiring rigorous quantification, such as gene expression analysis and viral load measurement.
Figure 1. Improved Results with NOTABLE. Results from ABLE Labs' qRT-PCR targeting microRNA demonstrate reproducible Ct values similar to manual results. Furthermore, high R2 values in qRT-PCR with NOTABLE indicate more precise aspiration and dispensing.
2. Consistency
Consistency in experimental procedures is essential for the reliability and reproducibility of scientific research. Automated systems ensure that experimental protocols are executed uniformly, significantly reducing the variability associated with manual processes. This uniformity is crucial for the comparability of results across different experiments and over time, thereby enhancing the overall reliability of research findings.
At ABLE Labs, the use of NOTABLE for PCR sample preparation has resulted in a more consistent distribution of coefficient of variation (CV) values, indicating reduced variability and enhanced reproducibility. This consistency extends beyond PCR preparation to other critical processes, such as nucleic acid extraction using NOTABLE’s Magnetic module. Consistent and reliable nucleic acid extraction is fundamental for downstream applications, including sequencing, cloning, and diagnostic assays.
Moreover, the robustness of automated systems like NOTABLE ensures that high standards of experimental quality are maintained regardless of changes in laboratory personnel. This is particularly important in research environments where staff turnover can disrupt experimental consistency and data integrity. By providing a stable and reproducible platform, NOTABLE mitigates the risks associated with human variability and turnover, ensuring continuity and reliability in research outcomes.
Figure 2. Consistent Data. NOTABLE provides consistent data in PCR sample preparation and nucleic acid extraction processes. This ensures improved research quality and guarantees reproducibility.